Clonal hematopoiesis associated with epigenetic aging and clinical outcomes

Clonal hematopoiesis of indeterminate potential (CHIP) is a common precursor state for blood cancers that most frequently occurs due to mutations in the DNA‐methylation modifying enzymes DNMT3A or TET2. We used DNA‐methylation array and whole‐genome sequencing data from four cohorts together compris...

Full description

Saved in:
Bibliographic Details
Published in:Aging Cell
Main Authors: Nachun, Daniel, Lu, Ake T., Bick, Alexander G., Natarajan, Pradeep, Weinstock, Joshua, Szeto, Mindy D., Kathiresan, Sekar, Abecasis, Goncalo, Taylor, Kent D., Guo, Xiuqing, Tracy, Russ, Durda, Peter, Liu, Yongmei, Johnson, Craig, Rich, Stephen S., Van Den Berg, David, Laurie, Cecilia, Blackwell, Tom, Papanicolaou, George J., Correa, Adolfo, Raffield, Laura M., Johnson, Andrew D., Murabito, Joanne, Manson, JoAnn E., Desai, Pinkal, Kooperberg, Charles, Assimes, Themistocles L., Levy, Daniel, Rotter, Jerome I., Reiner, Alex P., Whitsel, Eric A., Wilson, James G., Horvath, Steve, Jaiswal, Siddhartha
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2021
Subjects:
Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8208788/
https://ncbi.nlm.nih.gov/pubmed/34050697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.13366
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items