Clonal hematopoiesis associated with epigenetic aging and clinical outcomes

Clonal hematopoiesis of indeterminate potential (CHIP) is a common precursor state for blood cancers that most frequently occurs due to mutations in the DNA‐methylation modifying enzymes DNMT3A or TET2. We used DNA‐methylation array and whole‐genome sequencing data from four cohorts together compris...

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Vydáno v:Aging Cell
Hlavní autoři: Nachun, Daniel, Lu, Ake T., Bick, Alexander G., Natarajan, Pradeep, Weinstock, Joshua, Szeto, Mindy D., Kathiresan, Sekar, Abecasis, Goncalo, Taylor, Kent D., Guo, Xiuqing, Tracy, Russ, Durda, Peter, Liu, Yongmei, Johnson, Craig, Rich, Stephen S., Van Den Berg, David, Laurie, Cecilia, Blackwell, Tom, Papanicolaou, George J., Correa, Adolfo, Raffield, Laura M., Johnson, Andrew D., Murabito, Joanne, Manson, JoAnn E., Desai, Pinkal, Kooperberg, Charles, Assimes, Themistocles L., Levy, Daniel, Rotter, Jerome I., Reiner, Alex P., Whitsel, Eric A., Wilson, James G., Horvath, Steve, Jaiswal, Siddhartha
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2021
Témata:
Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8208788/
https://ncbi.nlm.nih.gov/pubmed/34050697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.13366
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