Clonal hematopoiesis associated with epigenetic aging and clinical outcomes

Clonal hematopoiesis of indeterminate potential (CHIP) is a common precursor state for blood cancers that most frequently occurs due to mutations in the DNA‐methylation modifying enzymes DNMT3A or TET2. We used DNA‐methylation array and whole‐genome sequencing data from four cohorts together compris...

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Bibliografiske detaljer
Udgivet i:Aging Cell
Main Authors: Nachun, Daniel, Lu, Ake T., Bick, Alexander G., Natarajan, Pradeep, Weinstock, Joshua, Szeto, Mindy D., Kathiresan, Sekar, Abecasis, Goncalo, Taylor, Kent D., Guo, Xiuqing, Tracy, Russ, Durda, Peter, Liu, Yongmei, Johnson, Craig, Rich, Stephen S., Van Den Berg, David, Laurie, Cecilia, Blackwell, Tom, Papanicolaou, George J., Correa, Adolfo, Raffield, Laura M., Johnson, Andrew D., Murabito, Joanne, Manson, JoAnn E., Desai, Pinkal, Kooperberg, Charles, Assimes, Themistocles L., Levy, Daniel, Rotter, Jerome I., Reiner, Alex P., Whitsel, Eric A., Wilson, James G., Horvath, Steve, Jaiswal, Siddhartha
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2021
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Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8208788/
https://ncbi.nlm.nih.gov/pubmed/34050697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.13366
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