Amino Acid Transporter Slc38a5 Controls Glucagon Receptor Inhibition-Induced Pancreatic α Cell Hyperplasia in Mice

Glucagon supports glucose homeostasis by stimulating hepatic gluconeogenesis, in part by promoting the uptake and conversion of amino acids into gluconeogenic precursors. Genetic disruption or pharmacologic inhibition of glucagon signaling results in elevated plasma amino acids and compensatory gluc...

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Détails bibliographiques
Publié dans:Cell Metab
Auteurs principaux: Kim, Jinrang, Okamoto, Haruka, Huang, ZhiJiang, Anguiano, Guillermo, Chen, Shiuhwei, Liu, Qing, Cavino, Katie, Xin, Yurong, Na, Erqian, Hamid, Rachid, Lee, Joseph, Zambrowicz, Brian, Unger, Roger, Murphy, Andrew J., Xu, Yan, Yancopoulos, George D., Li, Wen-hong, Gromada, Jesper
Format: Artigo
Langue:Inglês
Publié: 2017
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8206958/
https://ncbi.nlm.nih.gov/pubmed/28591637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2017.05.006
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