Glucagon receptor inhibition normalizes blood glucose in severe insulin-resistant mice

Inactivating mutations in the insulin receptor results in extreme insulin resistance. The resulting hyperglycemia is very difficult to treat, and patients are at risk for early morbidity and mortality from complications of diabetes. We used the insulin receptor antagonist S961 to induce severe insul...

Cur síos iomlán

Na minha lista:
Sonraí Bibleagrafaíochta
Foilsithe in:Proc Natl Acad Sci U S A
Main Authors: Okamoto, Haruka, Cavino, Katie, Na, Erqian, Krumm, Elizabeth, Kim, Sun Y., Cheng, Xiping, Murphy, Andrew J., Yancopoulos, George D., Gromada, Jesper
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2017
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5347550/
https://ncbi.nlm.nih.gov/pubmed/28115707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1621069114
Clibeanna: Cuir Clib Leis
Gan Chlibeanna, Bí ar an gcéad duine leis an taifead seo a chlibeáil!

Míreanna Comhchosúla