Glucagon receptor inhibition normalizes blood glucose in severe insulin-resistant mice

Inactivating mutations in the insulin receptor results in extreme insulin resistance. The resulting hyperglycemia is very difficult to treat, and patients are at risk for early morbidity and mortality from complications of diabetes. We used the insulin receptor antagonist S961 to induce severe insul...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Okamoto, Haruka, Cavino, Katie, Na, Erqian, Krumm, Elizabeth, Kim, Sun Y., Cheng, Xiping, Murphy, Andrew J., Yancopoulos, George D., Gromada, Jesper
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2017
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5347550/
https://ncbi.nlm.nih.gov/pubmed/28115707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1621069114
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