Lasp1 regulates adherens junction dynamics and fibroblast transformation in destructive arthritis

The LIM and SH3 domain protein 1 (Lasp1) was originally cloned from metastatic breast cancer and characterised as an adaptor molecule associated with tumourigenesis and cancer cell invasion. However, the regulation of Lasp1 and its function in the aggressive transformation of cells is unclear. Here...

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Pubblicato in:Nat Commun
Autori principali: Beckmann, Denise, Römer-Hillmann, Anja, Krause, Annika, Hansen, Uwe, Wehmeyer, Corinna, Intemann, Johanna, de Gorter, David J. J., Dankbar, Berno, Hillen, Jan, Heitzmann, Marianne, Begemann, Isabell, Galic, Milos, Weinhage, Toni, Foell, Dirk, Ai, Rizi, Kremerskothen, Joachim, Kiener, Hans P., Müller, Sylvia, Kamradt, Thomas, Schröder, Christopher, Leitão, Elsa, Horsthemke, Bernhard, Rosenstiel, Philip, Nordström, Karl, Gasparoni, Gilles, Gasparoni, Nina, Walter, Jörn, Li, Na, Yang, Xinyi, Chung, Ho-Ryun, Pavenstädt, Hermann, Lindemann, Nico, Schnittler, Hans J., Wang, Wei, Firestein, Gary S., Pap, Thomas, Korb-Pap, Adelheid
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2021
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8206096/
https://ncbi.nlm.nih.gov/pubmed/34131132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-23706-8
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