Inhibition of Histone Deacetylases 1, 2, and 3 Enhances Clearance of Cholesterol Accumulation in Niemann-Pick C1 Fibroblasts

[Image: see text] Niemann-Pick disease type C1 (NPC1) is a rare genetic cholesterol storage disorder caused by mutations in the NPC1 gene. Mutations in this transmembrane late endosome protein lead to loss of normal cholesterol efflux from late endosomes and lysosomes. It has been shown that broad s...

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Udgivet i:ACS Pharmacol Transl Sci
Main Authors: Cruz, Dana L., Pipalia, Nina, Mao, Shu, Gadi, Deepti, Liu, Gang, Grigalunas, Michael, O’Neill, Matthew, Quinn, Taylor R., Kipper, Andi, Ekebergh, Andreas, Dimmling, Alexander, Gartner, Carlos, Melancon, Bruce J., Wagner, Florence F., Holson, Edward, Helquist, Paul, Wiest, Olaf, Maxfield, Frederick R.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2021
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8204796/
https://ncbi.nlm.nih.gov/pubmed/34151204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsptsci.1c00033
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