Inhibition of Histone Deacetylases 1, 2, and 3 Enhances Clearance of Cholesterol Accumulation in Niemann-Pick C1 Fibroblasts

[Image: see text] Niemann-Pick disease type C1 (NPC1) is a rare genetic cholesterol storage disorder caused by mutations in the NPC1 gene. Mutations in this transmembrane late endosome protein lead to loss of normal cholesterol efflux from late endosomes and lysosomes. It has been shown that broad s...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:ACS Pharmacol Transl Sci
Autores principales: Cruz, Dana L., Pipalia, Nina, Mao, Shu, Gadi, Deepti, Liu, Gang, Grigalunas, Michael, O’Neill, Matthew, Quinn, Taylor R., Kipper, Andi, Ekebergh, Andreas, Dimmling, Alexander, Gartner, Carlos, Melancon, Bruce J., Wagner, Florence F., Holson, Edward, Helquist, Paul, Wiest, Olaf, Maxfield, Frederick R.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2021
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8204796/
https://ncbi.nlm.nih.gov/pubmed/34151204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsptsci.1c00033
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares