Functional Selectivity of a Biased Cannabinoid-1 Receptor (CB(1)R) Antagonist

[Image: see text] Seven-transmembrane receptors signal via G-protein- and β-arrestin-dependent pathways. We describe a peripheral CB(1)R antagonist (MRI-1891) highly biased toward inhibiting CB(1)R-induced β-arrestin-2 (βArr2) recruitment over G-protein activation. In obese wild-type and βArr2-knock...

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Publicat a:ACS Pharmacol Transl Sci
Autors principals: Liu, Ziyi, Iyer, Malliga R., Godlewski, Grzegorz, Jourdan, Tony, Liu, Jie, Coffey, Nathan J., Zawatsky, Charles N., Puhl, Henry L., Wess, Jürgen, Meister, Jaroslawna, Liow, Jeih-San, Innis, Robert B., Hassan, Sergio A., Lee, Yong Sok, Kunos, George, Cinar, Resat
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2021
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8204328/
https://ncbi.nlm.nih.gov/pubmed/34151207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsptsci.1c00048
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