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Cannabinoid-1 Receptor Antagonism Improves Glycemic Control and Increases Energy Expenditure via Sirt1/mTORC2 and AMPK Signaling
Endocannabinoids promote energy conservation in obesity, whereas cannabinoid-1 receptor (CB(1)R) blockade reverses body weight gain and insulin resistance and increases energy expenditure. Here we investigated the molecular mechanisms of the catabolic effects of CB(1)R blockade in the liver. Exposur...
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| Pubblicato in: | Hepatology |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6438767/ https://ncbi.nlm.nih.gov/pubmed/30506571 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.30364 |
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