Cannabinoid-1 Receptor Antagonism Improves Glycemic Control and Increases Energy Expenditure via Sirt1/mTORC2 and AMPK Signaling

Endocannabinoids promote energy conservation in obesity, whereas cannabinoid-1 receptor (CB(1)R) blockade reverses body weight gain and insulin resistance and increases energy expenditure. Here we investigated the molecular mechanisms of the catabolic effects of CB(1)R blockade in the liver. Exposur...

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Bibliografiska uppgifter
I publikationen:Hepatology
Huvudupphovsmän: Liu, Jie, Godlewski, Grzegorz, Jourdan, Tony, Liu, Ziyi, Cinar, Resat, Xiong, Keming, Kunos, George
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2019
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6438767/
https://ncbi.nlm.nih.gov/pubmed/30506571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.30364
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