Melanoma dedifferentiation induced by IFN-γ epigenetic remodeling in response to anti–PD-1 therapy

Melanoma dedifferentiation has been reported to be a state of cellular resistance to targeted therapies and immunotherapies as cancer cells revert to a more primitive cellular phenotype. Here, we show that, counterintuitively, the biopsies of patient tumors that responded to anti–programmed cell dea...

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Bibliographic Details
Published in:J Clin Invest
Main Authors: Kim, Yeon Joo, Sheu, Katherine M., Tsoi, Jennifer, Abril-Rodriguez, Gabriel, Medina, Egmidio, Grasso, Catherine S., Torrejon, Davis Y., Champhekar, Ameya S., Litchfield, Kevin, Swanton, Charles, Speiser, Daniel E., Scumpia, Philip O., Hoffmann, Alexander, Graeber, Thomas G., Puig-Saus, Cristina, Ribas, Antoni
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2021
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8203459/
https://ncbi.nlm.nih.gov/pubmed/33914706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI145859
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