Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression

PD-L1 and PD-L2 are ligands for the PD-1 immune inhibiting checkpoint that can be induced in tumors by interferon exposure, leading to immune evasion. This process is important for immunotherapy based on PD-1 blockade. We examined the specific molecules involved in interferon-induced signaling that...

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Udgivet i:Cell Rep
Main Authors: Garcia-Diaz, Angel, Shin, Daniel Sanghoon, Moreno, Blanca Homet, Saco, Justin, Escuin-Ordinas, Helena, Rodriguez, Gabriel Abril, Zaretsky, Jesse M., Sun, Lu, Hugo, Willy, Wang, Xiaoyan, Parisi, Giulia, Saus, Cristina Puig, Torrejon, Davis Y., Graeber, Thomas G., Comin-Anduix, Begonya, Hu-Lieskovan, Siwen, Damoiseaux, Robert, Lo, Roger S., Ribas, Antoni
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6420824/
https://ncbi.nlm.nih.gov/pubmed/28494868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.04.031
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