Overcoming genetically-based resistance mechanisms to PD-1 blockade

Mechanism-based strategies to overcome resistance to programmed cell death-1 (PD-1) blockade therapy are urgently needed. We developed genetic acquired resistant models of JAK1, JAK2 and B2M loss of function mutations by gene knockout in human and murine cell lines. Human melanoma cell lines with JA...

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Vydáno v:Cancer Discov
Hlavní autoři: Torrejon, Davis Y., Abril-Rodriguez, Gabriel, Champhekar, Ameya S., Tsoi, Jennifer, Campbell, Katie M., Kalbasi, Anusha, Parisi, Giulia, Zarestsky, Jesse M., Garcia-Diaz, Angel, Puig-Saus, Cristina, Cheung-Lau, Gardenia, Wohlwender, Thomas, Krystofinski, Paige, Vega-Crespo, Agustin, Lee, Christopher M., Mascaro, Pau, Grasso, Catherine S., Berent-Maoz, Beata, Comin-Anduix, Begoña, Hu-Lieskovan, Siwen, Ribas, Antoni
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7416458/
https://ncbi.nlm.nih.gov/pubmed/32467343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-19-1409
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