Overcoming genetically-based resistance mechanisms to PD-1 blockade

Mechanism-based strategies to overcome resistance to programmed cell death-1 (PD-1) blockade therapy are urgently needed. We developed genetic acquired resistant models of JAK1, JAK2 and B2M loss of function mutations by gene knockout in human and murine cell lines. Human melanoma cell lines with JA...

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Publicado no:Cancer Discov
Main Authors: Torrejon, Davis Y., Abril-Rodriguez, Gabriel, Champhekar, Ameya S., Tsoi, Jennifer, Campbell, Katie M., Kalbasi, Anusha, Parisi, Giulia, Zarestsky, Jesse M., Garcia-Diaz, Angel, Puig-Saus, Cristina, Cheung-Lau, Gardenia, Wohlwender, Thomas, Krystofinski, Paige, Vega-Crespo, Agustin, Lee, Christopher M., Mascaro, Pau, Grasso, Catherine S., Berent-Maoz, Beata, Comin-Anduix, Begoña, Hu-Lieskovan, Siwen, Ribas, Antoni
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7416458/
https://ncbi.nlm.nih.gov/pubmed/32467343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-19-1409
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