GIPR agonism mediates weight-independent insulin sensitization by tirzepatide in obese mice

Tirzepatide (LY3298176), a dual GIP and GLP-1 receptor (GLP-1R) agonist, delivered superior glycemic control and weight loss compared with GLP-1R agonism in patients with type 2 diabetes. However, the mechanism by which tirzepatide improves efficacy and how GIP receptor (GIPR) agonism contributes is...

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Pubblicato in:J Clin Invest
Autori principali: Samms, Ricardo J., Christe, Michael E., Collins, Kyla A.L., Pirro, Valentina, Droz, Brian A., Holland, Adrienne K., Friedrich, Jessica L., Wojnicki, Samantha, Konkol, Debra L., Cosgrove, Richard, Furber, Ellen P.S. Conceição, Ruan, Xiaoping, O’Farrell, Libbey S., Long, Annie M., Dogra, Mridula, Willency, Jill A., Lin, Yanzhu, Ding, Liyun, Cheng, Christine C., Cabrera, Over, Briere, Daniel A., Alsina-Fernandez, Jorge, Gimeno, Ruth E., Moyers, Julie S., Coskun, Tamer, Coghlan, Matthew P., Sloop, Kyle W., Roell, William C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2021
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8203452/
https://ncbi.nlm.nih.gov/pubmed/34003802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI146353
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