GIPR agonism mediates weight-independent insulin sensitization by tirzepatide in obese mice

Tirzepatide (LY3298176), a dual GIP and GLP-1 receptor (GLP-1R) agonist, delivered superior glycemic control and weight loss compared with GLP-1R agonism in patients with type 2 diabetes. However, the mechanism by which tirzepatide improves efficacy and how GIP receptor (GIPR) agonism contributes is...

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Publicat a:J Clin Invest
Autors principals: Samms, Ricardo J., Christe, Michael E., Collins, Kyla A.L., Pirro, Valentina, Droz, Brian A., Holland, Adrienne K., Friedrich, Jessica L., Wojnicki, Samantha, Konkol, Debra L., Cosgrove, Richard, Furber, Ellen P.S. Conceição, Ruan, Xiaoping, O’Farrell, Libbey S., Long, Annie M., Dogra, Mridula, Willency, Jill A., Lin, Yanzhu, Ding, Liyun, Cheng, Christine C., Cabrera, Over, Briere, Daniel A., Alsina-Fernandez, Jorge, Gimeno, Ruth E., Moyers, Julie S., Coskun, Tamer, Coghlan, Matthew P., Sloop, Kyle W., Roell, William C.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2021
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8203452/
https://ncbi.nlm.nih.gov/pubmed/34003802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI146353
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