Chronic glucose-dependent insulinotropic polypeptide receptor (GIPR) agonism desensitizes adipocyte GIPR activity mimicking functional GIPR antagonism

Antagonism or agonism of the glucose-dependent insulinotropic polypeptide (GIP) receptor (GIPR) prevents weight gain and leads to dramatic weight loss in combination with glucagon-like peptide-1 receptor agonists in preclinical models. Based on the genetic evidence supporting GIPR antagonism, we pre...

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Publicado no:Nat Commun
Main Authors: Killion, Elizabeth A., Chen, Michelle, Falsey, James R., Sivits, Glenn, Hager, Todd, Atangan, Larissa, Helmering, Joan, Lee, Jae, Li, Hongyan, Wu, Bin, Cheng, Yuan, Véniant, Murielle M., Lloyd, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7536395/
https://ncbi.nlm.nih.gov/pubmed/33020469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18751-8
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