GIPR agonism mediates weight-independent insulin sensitization by tirzepatide in obese mice

Tirzepatide (LY3298176), a dual GIP and GLP-1 receptor (GLP-1R) agonist, delivered superior glycemic control and weight loss compared with GLP-1R agonism in patients with type 2 diabetes. However, the mechanism by which tirzepatide improves efficacy and how GIP receptor (GIPR) agonism contributes is...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Samms, Ricardo J., Christe, Michael E., Collins, Kyla A.L., Pirro, Valentina, Droz, Brian A., Holland, Adrienne K., Friedrich, Jessica L., Wojnicki, Samantha, Konkol, Debra L., Cosgrove, Richard, Furber, Ellen P.S. Conceição, Ruan, Xiaoping, O’Farrell, Libbey S., Long, Annie M., Dogra, Mridula, Willency, Jill A., Lin, Yanzhu, Ding, Liyun, Cheng, Christine C., Cabrera, Over, Briere, Daniel A., Alsina-Fernandez, Jorge, Gimeno, Ruth E., Moyers, Julie S., Coskun, Tamer, Coghlan, Matthew P., Sloop, Kyle W., Roell, William C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8203452/
https://ncbi.nlm.nih.gov/pubmed/34003802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI146353
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