Tofacitinib inhibits inflammatory cytokines from ulcerative colitis and healthy mucosal explants and is associated with pSTAT1/3 reduction in T-cells

Poor translatability of animal disease models has hampered the development of new inflammatory bowel disorder (IBD) therapeutics. We describe a preclinical, ex vivo system using freshly obtained and well-characterized human colorectal tissue from patients with ulcerative colitis (UC) and healthy con...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:Am J Physiol Gastrointest Liver Physiol
Huvudupphovsmän: Brand, Rhonda M., Moore, Beverley A., Zyhowski, Ashley, Siegel, Aaron, Uttam, Shikhar, Metter, E. Jeffrey, Engstrom, Jarret, Brand, Randall E., Biswas, Nabanita, Whitcomb, David C., Binion, David G., Schwartz, Marc, McGowan, Ian
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Physiological Society 2021
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC8202239/
https://ncbi.nlm.nih.gov/pubmed/33355506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00383.2020
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk