Tofacitinib inhibits inflammatory cytokines from ulcerative colitis and healthy mucosal explants and is associated with pSTAT1/3 reduction in T-cells

Poor translatability of animal disease models has hampered the development of new inflammatory bowel disorder (IBD) therapeutics. We describe a preclinical, ex vivo system using freshly obtained and well-characterized human colorectal tissue from patients with ulcerative colitis (UC) and healthy con...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Am J Physiol Gastrointest Liver Physiol
Main Authors: Brand, Rhonda M., Moore, Beverley A., Zyhowski, Ashley, Siegel, Aaron, Uttam, Shikhar, Metter, E. Jeffrey, Engstrom, Jarret, Brand, Randall E., Biswas, Nabanita, Whitcomb, David C., Binion, David G., Schwartz, Marc, McGowan, Ian
פורמט: Artigo
שפה:Inglês
יצא לאור: American Physiological Society 2021
נושאים:
Research Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC8202239/
https://ncbi.nlm.nih.gov/pubmed/33355506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00383.2020
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