Tofacitinib inhibits inflammatory cytokines from ulcerative colitis and healthy mucosal explants and is associated with pSTAT1/3 reduction in T-cells

Poor translatability of animal disease models has hampered the development of new inflammatory bowel disorder (IBD) therapeutics. We describe a preclinical, ex vivo system using freshly obtained and well-characterized human colorectal tissue from patients with ulcerative colitis (UC) and healthy con...

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Publicat a:Am J Physiol Gastrointest Liver Physiol
Autors principals: Brand, Rhonda M., Moore, Beverley A., Zyhowski, Ashley, Siegel, Aaron, Uttam, Shikhar, Metter, E. Jeffrey, Engstrom, Jarret, Brand, Randall E., Biswas, Nabanita, Whitcomb, David C., Binion, David G., Schwartz, Marc, McGowan, Ian
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2021
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8202239/
https://ncbi.nlm.nih.gov/pubmed/33355506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00383.2020
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