Tofacitinib inhibits inflammatory cytokines from ulcerative colitis and healthy mucosal explants and is associated with pSTAT1/3 reduction in T-cells

Poor translatability of animal disease models has hampered the development of new inflammatory bowel disorder (IBD) therapeutics. We describe a preclinical, ex vivo system using freshly obtained and well-characterized human colorectal tissue from patients with ulcerative colitis (UC) and healthy con...

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Detalhes bibliográficos
Publicado no:Am J Physiol Gastrointest Liver Physiol
Main Authors: Brand, Rhonda M., Moore, Beverley A., Zyhowski, Ashley, Siegel, Aaron, Uttam, Shikhar, Metter, E. Jeffrey, Engstrom, Jarret, Brand, Randall E., Biswas, Nabanita, Whitcomb, David C., Binion, David G., Schwartz, Marc, McGowan, Ian
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8202239/
https://ncbi.nlm.nih.gov/pubmed/33355506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00383.2020
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