Inhibition of pSTAT1 by tofacitinib accounts for the early improvement of experimental chronic synovitis

BACKGROUND: In order to gain insight into the early effects drawn by JAK inhibitors on intra-joint JAK/STAT-dependent signaling, we sought synovial activation of STATs and their end-products, along with their modification with tofacitinib (TOFA), at flare-up in antigen induced arthritis (AIA). New Z...

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Vydáno v:J Inflamm (Lond)
Hlavní autoři: Pérez-Baos, Sandra, Gratal, Paula, Barrasa, Juan I., Lamuedra, Ana, Sánchez-Pernaute, Olga, Herrero-Beaumont, Gabriel, Largo, Raquel
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2019
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6352431/
https://ncbi.nlm.nih.gov/pubmed/30728752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12950-019-0206-2
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