Mitochondrial apoptotic priming is a key determinant of cell fate upon p53 restoration

Reactivation of p53 in established tumors typically results in one of two cell fates, cell cycle arrest or apoptosis, but it remains unclear how this cell fate is determined. We hypothesized that high mitochondrial priming prior to p53 reactivation would lead to apoptosis, while low priming would le...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Autores principales: Sánchez-Rivera, Francisco J., Ryan, Jeremy, Soto-Feliciano, Yadira M., Clare Beytagh, Mary, Xuan, Lucius, Feldser, David M., Hemann, Michael T., Zamudio, Jesse, Dimitrova, Nadya, Letai, Anthony, Jacks, Tyler
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8201929/
https://ncbi.nlm.nih.gov/pubmed/34074758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2019740118
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