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Heightened mitochondrial priming is the basis for apoptotic hypersensitivity of CD4(+) CD8(+) thymocytes

It is well established that CD4(+) CD8(+) thymocytes are more sensitive to myriad death stimuli than CD4(+) or CD8(+) single positive (SP) thymocytes. The mechanism behind this hypersensitivity to apoptosis of CD4(+) CD8(+) thymocytes is not understood. To test whether the difference lay in the apop...

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Autori principali: Ryan, Jeremy A., Brunelle, Joslyn K., Letai, Anthony
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2919900/
https://ncbi.nlm.nih.gov/pubmed/20615979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0914878107
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