Mitochondrial apoptotic priming is a key determinant of cell fate upon p53 restoration

Reactivation of p53 in established tumors typically results in one of two cell fates, cell cycle arrest or apoptosis, but it remains unclear how this cell fate is determined. We hypothesized that high mitochondrial priming prior to p53 reactivation would lead to apoptosis, while low priming would le...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Sánchez-Rivera, Francisco J., Ryan, Jeremy, Soto-Feliciano, Yadira M., Clare Beytagh, Mary, Xuan, Lucius, Feldser, David M., Hemann, Michael T., Zamudio, Jesse, Dimitrova, Nadya, Letai, Anthony, Jacks, Tyler
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8201929/
https://ncbi.nlm.nih.gov/pubmed/34074758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2019740118
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