Mitochondrial apoptotic priming is a key determinant of cell fate upon p53 restoration

Reactivation of p53 in established tumors typically results in one of two cell fates, cell cycle arrest or apoptosis, but it remains unclear how this cell fate is determined. We hypothesized that high mitochondrial priming prior to p53 reactivation would lead to apoptosis, while low priming would le...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Sánchez-Rivera, Francisco J., Ryan, Jeremy, Soto-Feliciano, Yadira M., Clare Beytagh, Mary, Xuan, Lucius, Feldser, David M., Hemann, Michael T., Zamudio, Jesse, Dimitrova, Nadya, Letai, Anthony, Jacks, Tyler
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2021
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8201929/
https://ncbi.nlm.nih.gov/pubmed/34074758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2019740118
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