Stage-specific sensitivity to p53 restoration during lung cancer progression

Tumourigenesis is a multistep process that results from the sequential accumulation of mutations in key oncogene and tumour suppressor pathways. Personalized cancer therapy that is based on targeting these underlying genetic abnormalities presupposes that sustained inactivation of tumour suppressors...

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Detalhes bibliográficos
Main Authors: Feldser, David M., Kostova, Kamena K., Winslow, Monte M., Taylor, Sarah E., Cashman, Chris, Whittaker, Charles A., Sanchez-Rivera, Francisco J., Resnick, Rebecca, Bronson, Roderick, Hemann, Michael T., Jacks, Tyler
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003305/
https://ncbi.nlm.nih.gov/pubmed/21107428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature09535
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