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Stage-specific sensitivity to p53 restoration during lung cancer progression

Tumourigenesis is a multistep process that results from the sequential accumulation of mutations in key oncogene and tumour suppressor pathways. Personalized cancer therapy that is based on targeting these underlying genetic abnormalities presupposes that sustained inactivation of tumour suppressors...

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Bibliografiske detaljer
Main Authors: Feldser, David M., Kostova, Kamena K., Winslow, Monte M., Taylor, Sarah E., Cashman, Chris, Whittaker, Charles A., Sanchez-Rivera, Francisco J., Resnick, Rebecca, Bronson, Roderick, Hemann, Michael T., Jacks, Tyler
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003305/
https://ncbi.nlm.nih.gov/pubmed/21107428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature09535
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