Constitutive p53 heightens mitochondrial apoptotic priming and favors cell death induction by BH3 mimetic inhibitors of BCL-xL

Proapoptotic molecules directly targeting the BCL-2 family network are promising anticancer therapeutics, but an understanding of the cellular stress signals that render them effective is still elusive. We show here that the tumor suppressor p53, at least in part by transcription independent mechani...

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Dettagli Bibliografici
Pubblicato in:Cell Death Dis
Autori principali: Le Pen, J, Laurent, M, Sarosiek, K, Vuillier, C, Gautier, F, Montessuit, S, Martinou, J C, Letaï, A, Braun, F, Juin, P P
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4849148/
https://ncbi.nlm.nih.gov/pubmed/26844698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2015.400
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