pRb/E2F-1-mediated caspase-dependent induction of Noxa amplifies the apoptotic effects of the Bcl-2/Bcl-xL inhibitor ABT-737

Although Bcl-2 family members control caspase activity by regulating mitochondrial permeability, caspases can, in turn, amplify the apoptotic process upstream of mitochondria by ill-characterized mechanisms. We herein show that treatment with a potent inhibitor of Bcl-2 and Bcl-xL, ABT-737, triggers...

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Detalhes bibliográficos
Main Authors: Bertin-Ciftci, J, Barré, B, Le Pen, J, Maillet, L, Couriaud, C, Juin, P, Braun, F
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3619243/
https://ncbi.nlm.nih.gov/pubmed/23429261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2013.6
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