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Suppression of the kinase for elongation factor 2 alleviates mGluR-LTD impairments in a mouse model of Alzheimer’s disease

Impaired mRNA translation (protein synthesis) is linked to Alzheimer’s disease (AD) pathophysiology. Recent studies revealed a role of increased phosphorylation of eukaryotic elongation factor 2 (eEF2) in AD-associated cognitive deficits. Phosphorylation of eEF2 (at the Thr56 site) by its only known...

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Detalhes bibliográficos
Publicado no:Neurobiol Aging
Main Authors: Yang, Wenzhong, Zhou, Xueyan, Ryazanov, Alexey G., Ma, Tao
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8201868/
https://ncbi.nlm.nih.gov/pubmed/33341653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2020.11.016
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