Elongation Factor 2 and Fragile X Mental Retardation Protein Control the Dynamic Translation of Arc/Arg3.1 Essential for mGluR-LTD

Group I metabotropic glutamate receptors (mGluR) induce long-term depression (LTD) that requires protein synthesis. Here, we demonstrate that Arc/Arg3.1 is translationally induced within 5 min of mGluR activation, and this response is essential for mGluR-dependent LTD. The increase in Arc/Arg3.1 tra...

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Detalhes bibliográficos
Main Authors: Park, Sungjin, Park, Joo Min, Kim, Sangmok, Kim, Jin-Ah, Shepherd, Jason D., Smith-Hicks, Constance L., Chowdhury, Shoaib, Kaufmann, Walter, Kuhl, Dietmar, Ryazanov, Alexey G., Huganir, Richard L., Linden, David J., Worley, Paul F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2743934/
https://ncbi.nlm.nih.gov/pubmed/18614030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2008.05.023
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