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Repression of the eIF2α kinase PERK alleviates mGluR-LTD impairments in a mouse model of Alzheimer’s disease

Mounting evidence indicates that impairments of synaptic efficacy/plasticity may be a key step in the development of Alzheimer’s disease (AD) pathophysiology. Among the two major forms of synaptic plasticity, long-term potentiation (LTP) and long-term depression (LTD), much less is known about how L...

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Detalhes bibliográficos
Publicado no:Neurobiol Aging
Main Authors: Yang, Wenzhong, Zhou, Xueyan, Zimmermann, Helena, Cavener, Douglas R, Klann, Eric, Ma, Tao
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4841914/
https://ncbi.nlm.nih.gov/pubmed/27103515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2016.02.005
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