Brain-specific Disruption of the eIF2α Kinase PERK Decreases ATF4 Expression and Impairs Behavioral Flexibility

Translational control depends on phosphorylation of eIF2α by PKR-like ER kinase (PERK). To examine the role of PERK in cognitive function, we selectively disrupted PERK expression in the adult mouse forebrain. In the prefrontal cortex (PFC) of PERK-deficient mice, eIF2α phosphorylation and ATF4 expr...

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Detalhes bibliográficos
Main Authors: Trinh, Mimi A., Kaphzan, Hanoch, Wek, Ronald C., Pierre, Philippe, Cavener, Douglas R., Klann, Eric
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3401382/
https://ncbi.nlm.nih.gov/pubmed/22813743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2012.04.010
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