Genetic reduction of eEF2 kinase alleviates pathophysiology in Alzheimer’s disease model mice

Molecular signaling mechanisms underlying Alzheimer’s disease (AD) remain unclear. Maintenance of memory and synaptic plasticity depend on de novo protein synthesis, dysregulation of which is implicated in AD. Recent studies showed AD-associated hyperphosphorylation of mRNA translation factor eukary...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Beckelman, Brenna C., Yang, Wenzhong, Kasica, Nicole P., Zimmermann, Helena R., Zhou, Xueyan, Keene, C. Dirk, Ryazanov, Alexey G., Ma, Tao
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6355242/
https://ncbi.nlm.nih.gov/pubmed/30667373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI122954
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