Genetic reduction of eEF2 kinase alleviates pathophysiology in Alzheimer’s disease model mice

Molecular signaling mechanisms underlying Alzheimer’s disease (AD) remain unclear. Maintenance of memory and synaptic plasticity depend on de novo protein synthesis, dysregulation of which is implicated in AD. Recent studies showed AD-associated hyperphosphorylation of mRNA translation factor eukary...

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Dades bibliogràfiques
Publicat a:J Clin Invest
Autors principals: Beckelman, Brenna C., Yang, Wenzhong, Kasica, Nicole P., Zimmermann, Helena R., Zhou, Xueyan, Keene, C. Dirk, Ryazanov, Alexey G., Ma, Tao
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6355242/
https://ncbi.nlm.nih.gov/pubmed/30667373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI122954
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