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Mining for METTL3 inhibitors to suppress cancer
The RNA methyltransferase METTL3 catalyzes N(6)-methyladenosine (m(6)A) modification of messenger RNAs (mRNAs). It is overexpressed in many types of cancer, including acute myelogenous leukemia (AML), and promotes cancer cell growth and tumorigenicity. Now, a selective small molecule inhibitor of ME...
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| Publicat a: | Nat Struct Mol Biol |
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| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2021
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8197751/ https://ncbi.nlm.nih.gov/pubmed/34040230 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-021-00606-5 |
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