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Mining for METTL3 inhibitors to suppress cancer
The RNA methyltransferase METTL3 catalyzes N(6)-methyladenosine (m(6)A) modification of messenger RNAs (mRNAs). It is overexpressed in many types of cancer, including acute myelogenous leukemia (AML), and promotes cancer cell growth and tumorigenicity. Now, a selective small molecule inhibitor of ME...
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| Udgivet i: | Nat Struct Mol Biol |
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| Main Authors: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2021
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8197751/ https://ncbi.nlm.nih.gov/pubmed/34040230 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-021-00606-5 |
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