Antibody-drug conjugates with dual payloads for combating breast tumor heterogeneity and drug resistance

Breast tumors generally consist of a diverse population of cells with varying gene expression profiles. Breast tumor heterogeneity is a major factor contributing to drug resistance, recurrence, and metastasis after chemotherapy. Antibody-drug conjugates (ADCs) are emerging chemotherapeutic agents wi...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Yamazaki, Chisato M., Yamaguchi, Aiko, Anami, Yasuaki, Xiong, Wei, Otani, Yoshihiro, Lee, Jangsoon, Ueno, Naoto T., Zhang, Ningyan, An, Zhiqiang, Tsuchikama, Kyoji
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8192907/
https://ncbi.nlm.nih.gov/pubmed/34112795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-23793-7
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