Discordant regulation of eIF2 kinase GCN2 and mTORC1 during nutrient stress

Appropriate regulation of the Integrated stress response (ISR) and mTORC1 signaling are central for cell adaptation to starvation for amino acids. Halofuginone (HF) is a potent inhibitor of aminoacylation of tRNA(Pro) with broad biomedical applications. Here, we show that in addition to translationa...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Misra, Jagannath, Holmes, Michael J, T. Mirek, Emily, Langevin, Michael, Kim, Hyeong-Geug, Carlson, Kenneth R, Watford, Malcolm, Dong, X Charlie, Anthony, Tracy G, Wek, Ronald C
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2021
Témata:
Molecular Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8191763/
https://ncbi.nlm.nih.gov/pubmed/34023907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkab362
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