Discordant regulation of eIF2 kinase GCN2 and mTORC1 during nutrient stress

Appropriate regulation of the Integrated stress response (ISR) and mTORC1 signaling are central for cell adaptation to starvation for amino acids. Halofuginone (HF) is a potent inhibitor of aminoacylation of tRNA(Pro) with broad biomedical applications. Here, we show that in addition to translationa...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Misra, Jagannath, Holmes, Michael J, T. Mirek, Emily, Langevin, Michael, Kim, Hyeong-Geug, Carlson, Kenneth R, Watford, Malcolm, Dong, X Charlie, Anthony, Tracy G, Wek, Ronald C
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2021
Assuntos:
Molecular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8191763/
https://ncbi.nlm.nih.gov/pubmed/34023907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkab362
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