Phase II Multicenter, Open‐Label Study of Oral ENMD‐2076 for the Treatment of Patients with Advanced Fibrolamellar Carcinoma

LESSONS LEARNED: The fibrolamellar carcinoma‐associated DNAJB1‐PRKACA gene fusion transcript RNA codes for the catalytic domain of protein kinase A and, thus, overexpression of Aurora kinase A. ENMD‐2076 showed a favorable toxicity profile. The limited results, one patient (3%) with a partial respon...

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書目詳細資料
發表在:Oncologist
Main Authors: Abou‐Alfa, Ghassan K., Mayer, Robert, Venook, Alan P., O'Neill, Allison F., Beg, Muhammad S., LaQuaglia, Michael, Kingham, Peter T., Kobos, Rachel, Basturk, Olca, Brennan, Cameron, Yopp, Adam, Harding, James J., Leong, Stephen, Crown, John, Hoti, Emir, Leonard, Gregory, Ly, Michele, Bradley, Mikaela, Valentino, Emily, Markowitz, David, Zukiwski, Alexander, Ren, Ken, Gordan, John D.
格式: Artigo
語言:Inglês
出版: John Wiley & Sons, Inc. 2020
主題:
Clinical Trial Results
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC8186410/
https://ncbi.nlm.nih.gov/pubmed/32154962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2020-0093
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