Phase II Multicenter, Open‐Label Study of Oral ENMD‐2076 for the Treatment of Patients with Advanced Fibrolamellar Carcinoma

LESSONS LEARNED: The fibrolamellar carcinoma‐associated DNAJB1‐PRKACA gene fusion transcript RNA codes for the catalytic domain of protein kinase A and, thus, overexpression of Aurora kinase A. ENMD‐2076 showed a favorable toxicity profile. The limited results, one patient (3%) with a partial respon...

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Bibliografiske detaljer
Udgivet i:Oncologist
Main Authors: Abou‐Alfa, Ghassan K., Mayer, Robert, Venook, Alan P., O'Neill, Allison F., Beg, Muhammad S., LaQuaglia, Michael, Kingham, Peter T., Kobos, Rachel, Basturk, Olca, Brennan, Cameron, Yopp, Adam, Harding, James J., Leong, Stephen, Crown, John, Hoti, Emir, Leonard, Gregory, Ly, Michele, Bradley, Mikaela, Valentino, Emily, Markowitz, David, Zukiwski, Alexander, Ren, Ken, Gordan, John D.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley & Sons, Inc. 2020
Fag:
Clinical Trial Results
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8186410/
https://ncbi.nlm.nih.gov/pubmed/32154962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2020-0093
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