A Multicenter Randomized Three‐Arm Phase II Study of (1) Everolimus, (2) Estrogen Deprivation Therapy (EDT) with Leuprolide + Letrozole, and (3) Everolimus + EDT in Patients with Unresectable Fibrolamellar Carcinoma

LESSONS LEARNED: FLC is a complex cancer with many implicated oncogenic pathways. Single or dual targeting does not appear to alter the natural history of the cancer, and novel therapeutics are needed. Estrogen deprivation therapy with letrozole and leuprolide, alone or in combination with the mTOR...

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Detalles Bibliográficos
Publicado en:Oncologist
Main Authors: El Dika, Imane, Mayer, Robert J., Venook, Alan P., Capanu, Marinela, LaQuaglia, Michael P., Kobos, Rachel, O'Neill, Allison F., Chou, Joanne F., Ly, Michele, Ang, Celina, O'Reilly, Eileen M., Gordan, John D., Abou‐Alfa, Ghassan K.
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley & Sons, Inc. 2020
Assuntos:
Clinical Trial Results
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7648371/
https://ncbi.nlm.nih.gov/pubmed/32400000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2020-0367
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