The role of SQSTM1 (p62) in mitochondrial function and clearance in human cortical neurons

Sequestosome-1 (SQSTM1/p62) is involved in cellular processes such as autophagy and metabolic reprogramming. Mutations resulting in the loss of function of SQSTM1 lead to neurodegenerative diseases including frontotemporal dementia. The pathogenic mechanism that contributes to SQSTM1-related neurode...

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Publicat a:Stem Cell Reports
Autors principals: Poon, Anna, Saini, Harpreet, Sethi, Siddharth, O'Sullivan, Gregory A., Plun-Favreau, Hélène, Wray, Selina, Dawson, Lee A., McCarthy, James M.
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8185463/
https://ncbi.nlm.nih.gov/pubmed/33891871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2021.03.030
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