The role of SQSTM1 (p62) in mitochondrial function and clearance in human cortical neurons

Sequestosome-1 (SQSTM1/p62) is involved in cellular processes such as autophagy and metabolic reprogramming. Mutations resulting in the loss of function of SQSTM1 lead to neurodegenerative diseases including frontotemporal dementia. The pathogenic mechanism that contributes to SQSTM1-related neurode...

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Bibliographic Details
Published in:Stem Cell Reports
Main Authors: Poon, Anna, Saini, Harpreet, Sethi, Siddharth, O'Sullivan, Gregory A., Plun-Favreau, Hélène, Wray, Selina, Dawson, Lee A., McCarthy, James M.
Format: Artigo
Language:Inglês
Published: Elsevier 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8185463/
https://ncbi.nlm.nih.gov/pubmed/33891871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2021.03.030
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