The role of SQSTM1 (p62) in mitochondrial function and clearance in human cortical neurons

Sequestosome-1 (SQSTM1/p62) is involved in cellular processes such as autophagy and metabolic reprogramming. Mutations resulting in the loss of function of SQSTM1 lead to neurodegenerative diseases including frontotemporal dementia. The pathogenic mechanism that contributes to SQSTM1-related neurode...

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Veröffentlicht in:Stem Cell Reports
Hauptverfasser: Poon, Anna, Saini, Harpreet, Sethi, Siddharth, O'Sullivan, Gregory A., Plun-Favreau, Hélène, Wray, Selina, Dawson, Lee A., McCarthy, James M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8185463/
https://ncbi.nlm.nih.gov/pubmed/33891871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2021.03.030
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