Phospholipids of APOE lipoproteins activate microglia in an isoform-specific manner in preclinical models of Alzheimer’s disease

APOE and Trem2 are major genetic risk factors for Alzheimer’s disease (AD), but how they affect microglia response to Aβ remains unclear. Here we report an APOE isoform-specific phospholipid signature with correlation between human APOEε3/3 and APOEε4/4 AD brain and lipoproteins from astrocyte condi...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Fitz, Nicholas F., Nam, Kyong Nyon, Wolfe, Cody M., Letronne, Florent, Playso, Brittany E., Iordanova, Bistra E., Kozai, Takashi D. Y., Biedrzycki, Richard J., Kagan, Valerian E., Tyurina, Yulia Y., Han, Xianlin, Lefterov, Iliya, Koldamova, Radosveta
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8184801/
https://ncbi.nlm.nih.gov/pubmed/34099706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-23762-0
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados