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Trem2 deficiency differentially affects phenotype and transcriptome of human APOE3 and APOE4 mice
BACKGROUND: Alzheimer’s Disease (AD) is a neurodegenerative disorder influenced by aging and genetic risk factors. The inheritance of APOEε4 and variants of Triggering Receptor Expressed on Myeloid cells 2 (TREM2) are major genetic risk factors for AD. Recent studies showed that APOE binds to TREM2,...
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| Publicado no: | Mol Neurodegener |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7379780/ https://ncbi.nlm.nih.gov/pubmed/32703241 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-020-00394-4 |
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