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Enantioselective hydrogenation of annulated arenes: controlled formation of multiple stereocenters in adjacent rings

We report a method for the enantioselective hydrogenation of annulated arenes using 4H-pyrido[1,2-a]pyrimidinones as substrates. The method selectively generates multiple stereocenters in adjacent rings leading to architecturally complex motifs, which resemble bioactive molecules. The mechanistic st...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Chem Sci
Prif Awduron: Wiesenfeldt, Mario P., Moock, Daniel, Paul, Daniel, Glorius, Frank
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Royal Society of Chemistry 2021
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8179591/
https://ncbi.nlm.nih.gov/pubmed/34163775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0sc07099h
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