Query-guided protein–protein interaction inhibitor discovery

Protein–protein interactions (PPIs) are central to biological mechanisms, and can serve as compelling targets for drug discovery. Yet, the discovery of small molecule inhibitors of PPIs remains challenging given the large and typically shallow topography of the interacting protein surfaces. Here, we...

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Veröffentlicht in:Chem Sci
Hauptverfasser: Celis, Sergio, Hobor, Fruzsina, James, Thomas, Bartlett, Gail J., Ibarra, Amaurys A., Shoemark, Deborah K., Hegedüs, Zsófia, Hetherington, Kristina, Woolfson, Derek N., Sessions, Richard B., Edwards, Thomas A., Andrews, David M., Nelson, Adam, Wilson, Andrew J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Royal Society of Chemistry 2021
Schlagworte:
Chemistry
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8179539/
https://ncbi.nlm.nih.gov/pubmed/34163731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d1sc00023c
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