Query-guided protein–protein interaction inhibitor discovery

Protein–protein interactions (PPIs) are central to biological mechanisms, and can serve as compelling targets for drug discovery. Yet, the discovery of small molecule inhibitors of PPIs remains challenging given the large and typically shallow topography of the interacting protein surfaces. Here, we...

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Publicat a:Chem Sci
Autors principals: Celis, Sergio, Hobor, Fruzsina, James, Thomas, Bartlett, Gail J., Ibarra, Amaurys A., Shoemark, Deborah K., Hegedüs, Zsófia, Hetherington, Kristina, Woolfson, Derek N., Sessions, Richard B., Edwards, Thomas A., Andrews, David M., Nelson, Adam, Wilson, Andrew J.
Format: Artigo
Idioma:Inglês
Publicat: The Royal Society of Chemistry 2021
Matèries:
Chemistry
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8179539/
https://ncbi.nlm.nih.gov/pubmed/34163731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d1sc00023c
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