Predicting and Experimentally Validating Hot-Spot Residues at Protein–Protein Interfaces

[Image: see text] Protein–protein interactions (PPIs) are vital to all biological processes. These interactions are often dynamic, sometimes transient, typically occur over large topographically shallow protein surfaces, and can exhibit a broad range of affinities. Considerable progress has been mad...

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Detalhes bibliográficos
Publicado no:ACS Chem Biol
Main Authors: Ibarra, Amaurys A., Bartlett, Gail J., Hegedüs, Zsöfia, Dutt, Som, Hobor, Fruzsina, Horner, Katherine A., Hetherington, Kristina, Spence, Kirstin, Nelson, Adam, Edwards, Thomas A., Woolfson, Derek N., Sessions, Richard B., Wilson, Andrew J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2019
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6804253/
https://ncbi.nlm.nih.gov/pubmed/31525028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b00560
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