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Relationship between Hot Spot Residues and Ligand Binding Hot Spots in Protein-Protein Interfaces
In the context of protein-protein interactions, the term “hot spot” refers to a residue or cluster of residues that makes a major contribution to the binding free energy, as determined by alanine scanning mutagenesis. In contrast, in pharmaceutical research a hot spot is a site on a target protein t...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3623692/ https://ncbi.nlm.nih.gov/pubmed/22770357 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ci300175u |
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