Загрузка...
Relationship between Hot Spot Residues and Ligand Binding Hot Spots in Protein-Protein Interfaces
In the context of protein-protein interactions, the term “hot spot” refers to a residue or cluster of residues that makes a major contribution to the binding free energy, as determined by alanine scanning mutagenesis. In contrast, in pharmaceutical research a hot spot is a site on a target protein t...
Сохранить в:
| Главные авторы: | , , , , |
|---|---|
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2012
|
| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3623692/ https://ncbi.nlm.nih.gov/pubmed/22770357 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ci300175u |
| Метки: |
Добавить метку
Нет меток, Требуется 1-ая метка записи!
|