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Relationship between Hot Spot Residues and Ligand Binding Hot Spots in Protein-Protein Interfaces

In the context of protein-protein interactions, the term “hot spot” refers to a residue or cluster of residues that makes a major contribution to the binding free energy, as determined by alanine scanning mutagenesis. In contrast, in pharmaceutical research a hot spot is a site on a target protein t...

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書目詳細資料
Main Authors: Zerbe, Brandon S., Hall, David R., Vajda, Sandor, Whitty, Adrian, Kozakov, Dima
格式: Artigo
語言:Inglês
出版: 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3623692/
https://ncbi.nlm.nih.gov/pubmed/22770357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ci300175u
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