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Structural conservation of druggable hot spots in protein–protein interfaces
Despite the growing number of examples of small-molecule inhibitors that disrupt protein–protein interactions (PPIs), the origin of druggability of such targets is poorly understood. To identify druggable sites in protein–protein interfaces we combine computational solvent mapping, which explores th...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3158149/ https://ncbi.nlm.nih.gov/pubmed/21808046 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1101835108 |
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